Ontology highlight
ABSTRACT:
SUBMITTER: Reppe S
PROVIDER: S-EPMC4687843 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Reppe Sjur S Wang Yunpeng Y Thompson Wesley K WK McEvoy Linda K LK Schork Andrew J AJ Zuber Verena V LeBlanc Marissa M Bettella Francesco F Mills Ian G IG Desikan Rahul S RS Djurovic Srdjan S Gautvik Kaare M KM Dale Anders M AM Andreassen Ole A OA
PloS one 20151222 12
Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucleotide polymorphisms (SNPs) associated with BMD by leveraging cardiovascular disease (CVD) associate ...[more]