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Systemic Antibiotics in Periodontal Treatment of Diabetic Patients: A Systematic Review.


ABSTRACT: To evaluate the effects of systemic antibiotics in combination with scaling and root planing (SRP) on periodontal parameters, tooth loss and oral health-related quality of life in diabetes patients.Two independent reviewers screened for controlled clinical trials with at least 6-month follow-up in six electronic databases, registers of clinical trials, meeting abstracts and four major dental journals. After duplicates removal, electronic and hand searches yielded 1,878 records; 18 full-text articles were independently read by two reviewers. To evaluate the additional effect of antibiotic usage, pooled weighted mean differences and 95% confidence intervals were calculated using a fixed effects model.Five studies met the inclusion criteria, four of which were included in meta-analyses. The meta-analyses showed a significant effect favouring SRP plus antibiotic for reductions in mean probing depth (PD) (-0.22 mm [-0.34, -0.11]) and mean percentage of bleeding on probing (BoP) (4% [-7, -1]). There was no significant effect for clinical attachment level gain and plaque index reduction. No study reported on tooth loss and oral health-related quality of life.Adjunctive systemic antibiotic use in diabetic patients provides a small additional benefit in terms of reductions in mean PD and mean percentage of BoP.CRD42013006389.

SUBMITTER: Santos CM 

PROVIDER: S-EPMC4687852 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Systemic Antibiotics in Periodontal Treatment of Diabetic Patients: A Systematic Review.

Santos Caroline Moura Martins Lobo CM   Lira-Junior Ronaldo R   Fischer Ricardo Guimarães RG   Santos Ana Paula Pires AP   Oliveira Branca Heloisa BH  

PloS one 20151222 12


<h4>Aim</h4>To evaluate the effects of systemic antibiotics in combination with scaling and root planing (SRP) on periodontal parameters, tooth loss and oral health-related quality of life in diabetes patients.<h4>Materials and methods</h4>Two independent reviewers screened for controlled clinical trials with at least 6-month follow-up in six electronic databases, registers of clinical trials, meeting abstracts and four major dental journals. After duplicates removal, electronic and hand searche  ...[more]

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