Dataset Information

1020MHz single-channel proton fast magic angle spinning solid-state NMR spectroscopy.

ABSTRACT: This study reports a first successful demonstration of a single channel proton 3D and 2D high-throughput ultrafast magic angle spinning (MAS) solid-state NMR techniques in an ultra-high magnetic field (1020MHz) NMR spectrometer comprised of HTS/LTS magnet. High spectral resolution is well demonstrated.

SUBMITTER: Pandey MK

PROVIDER: S-EPMC4688097 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

1020MHz single-channel proton fast magic angle spinning solid-state NMR spectroscopy.

Pandey Manoj Kumar MK Pandey Manoj Kumar MK Zhang Rongchun R Hashi Kenjiro K Ohki Shinobu S Nishijima Gen G Matsumoto Shinji S Noguchi Takashi T Deguchi Kenzo K Goto Atsushi A Shimizu Tadashi T Maeda Hideaki H Takahashi Masato M Yanagisawa Yoshinori Y Yamazaki Toshio T Iguchi Seiya S Tanaka Ryoji R Nemoto Takahiro T Miyamoto Tetsuo T Suematsu Hiroto H Saito Kazuyoshi K Miki Takashi T Ramamoorthy Ayyalusamy A Nishiyama Yusuke Y

Journal of magnetic resonance (San Diego, Calif. : 1997) 20151017

This study reports a first successful demonstration of a single channel proton 3D and 2D high-throughput ultrafast magic angle spinning (MAS) solid-state NMR techniques in an ultra-high magnetic field (1020MHz) NMR spectrometer comprised of HTS/LTS magnet. High spectral resolution is well demonstrated. ...[more]

PMID: 26524647

Similar Datasets

Project description:Solid-state NMR spectroscopy is one of the most commonly used techniques to study the atomic-resolution structure and dynamics of various chemical, biological, material, and pharmaceutical systems spanning multiple forms, including crystalline, liquid crystalline, fibrous, and amorphous states. Despite the unique advantages of solid-state NMR spectroscopy, its poor spectral resolution and sensitivity have severely limited the scope of this technique. Fortunately, the recent developments in probe technology that mechanically rotate the sample fast (100 kHz and above) to obtain "solution-like" NMR spectra of solids with higher resolution and sensitivity have opened numerous avenues for the development of novel NMR techniques and their applications to study a plethora of solids including globular and membrane-associated proteins, self-assembled protein aggregates such as amyloid fibers, RNA, viral assemblies, polymorphic pharmaceuticals, metal-organic framework, bone materials, and inorganic materials. While the ultrafast-MAS continues to be developed, the minute sample quantity and radio frequency requirements, shorter recycle delays enabling fast data acquisition, the feasibility of employing proton detection, enhancement in proton spectral resolution and polarization transfer efficiency, and high sensitivity per unit sample are some of the remarkable benefits of the ultrafast-MAS technology as demonstrated by the reported studies in the literature. Although the very low sample volume and very high RF power could be limitations for some of the systems, the advantages have spurred solid-state NMR investigation into increasingly complex biological and material systems. As ultrafast-MAS NMR techniques are increasingly used in multidisciplinary research areas, further development of instrumentation, probes, and advanced methods are pursued in parallel to overcome the limitations and challenges for widespread applications. This review article is focused on providing timely comprehensive coverage of the major developments on instrumentation, theory, techniques, applications, limitations, and future scope of ultrafast-MAS technology.

Dataset Information

1020MHz single-channel proton fast magic angle spinning solid-state NMR spectroscopy.

Publications

1020MHz single-channel proton fast magic angle spinning solid-state NMR spectroscopy.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets