Ontology highlight
ABSTRACT:
SUBMITTER: Makowska KA
PROVIDER: S-EPMC4688110 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Cell reports 20151206 10
We investigated the myosin expression profile in prostate cancer cell lines and found that Myo1b, Myo9b, Myo10, and Myo18a were expressed at higher levels in cells with high metastatic potential. Moreover, Myo1b and Myo10 were expressed at higher levels in metastatic tumors. Using an siRNA-based approach, we found that knockdown of each myosin resulted in distinct phenotypes. Myo10 knockdown ablated filopodia and decreased 2D migration speed. Myo18a knockdown increased circumferential non-muscle ...[more]