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Targeting KRAS-mutant non-small cell lung cancer: challenges and opportunities.

ABSTRACT: Oncogenic mutations in Kirsten rat sarcoma viral oncogene homolog (KRAS) occur in 15%-30% of non-small cell lung cancer (NSCLC). However, despite decades of intensive research, there is still no direct KRAS inhibitor with clinically proven efficacy. Considering its association with poor treatment response and prognosis of lung cancer, developing an effective inhibitory approach is urgently needed. Here, we review different strategies currently being explored to target KRAS-mutant NSCLC, discuss opportunities and challenges, and also propose some novel methods and concepts with the promise of clinical application.

SUBMITTER: Zhang J

PROVIDER: S-EPMC4689161 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Targeting KRAS-mutant non-small cell lung cancer: challenges and opportunities.

Zhang Jun J Park Dongkyoo D Shin Dong M DM Deng Xingming X

Acta biochimica et biophysica Sinica 20151117 1

Oncogenic mutations in Kirsten rat sarcoma viral oncogene homolog (KRAS) occur in 15%-30% of non-small cell lung cancer (NSCLC). However, despite decades of intensive research, there is still no direct KRAS inhibitor with clinically proven efficacy. Considering its association with poor treatment response and prognosis of lung cancer, developing an effective inhibitory approach is urgently needed. Here, we review different strategies currently being explored to target KRAS-mutant NSCLC, discuss ...[more]

PMID: 26578706

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