Ontology highlight
ABSTRACT:
SUBMITTER: Ard R
PROVIDER: S-EPMC4689489 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Ard Ryan R Mulatz Kirk K Pomoransky Julia L JL Parks Robin J RJ Trinkle-Mulcahy Laura L Bell John C JC Gee Stephen H SH
PloS one 20151223 12
Macropinosomes arise from the closure of plasma membrane ruffles to bring about the non-selective uptake of nutrients and solutes into cells. The morphological changes underlying ruffle formation and macropinosome biogenesis are driven by actin cytoskeleton rearrangements under the control of the Rho GTPase Rac1. We showed previously that Rac1 is activated by diacylglycerol kinase ζ (DGKζ), which phosphorylates diacylglycerol to yield phosphatidic acid. Here, we show DGKζ is required for optimal ...[more]