Computational Studies of Venom Peptides Targeting Potassium Channels.
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ABSTRACT:
SUBMITTER: Chen R
PROVIDER: S-EPMC4690127 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
Computational Studies of Venom Peptides Targeting Potassium Channels.
Toxins 20151201 12
Small peptides isolated from the venom of animals are potential scaffolds for ion channel drug discovery. This review article mainly focuses on the computational studies that have advanced our understanding of how various toxins interfere with the function of K⁺ channels. We introduce the computational tools available for the study of toxin-channel interactions. We then discuss how these computational tools have been fruitfully applied to elucidate the mechanisms of action of a wide range of ven ...[more]
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