Dataset Information

Molecular Mechanisms of Lipoic Acid Protection against Aflatoxin B?-Induced Liver Oxidative Damage and Inflammatory Responses in Broilers.

ABSTRACT: Alpha-lipoic acid (?-LA) was evaluated in this study for its molecular mechanisms against liver oxidative damage and inflammatory responses induced by aflatoxin B? (AFB?). Birds were randomly allocated into four groups with different diets for three weeks: a basal diet, a 300 mg/kg ?-LA supplementation in a basal diet, a diet containing 74 ?g/kg AFB?, and 300 mg/kg ?-LA supplementation in a diet containing 74 ?g/kg AFB?. In the AFB? group, the expression of GSH-PX mRNA was down-regulated (p < 0.05), and the levels of lipid peroxide and nitric oxide were increased (p < 0.05) in the chicken livers compared to those of the control group. Additionally, the mRNA level of the pro-inflammatory factor interleukin-6 was up-regulated significantly (p < 0.05), the protein expressions of both the nuclear factor kappa B (NF-?B) p65 and the inducible nitric oxide synthase were enhanced significantly (p < 0.05) in the AFB? group. All of these negative effects were inhibited by ?-LA. These results indicate that ?-LA may be effective in preventing hepatic oxidative stress, down-regulating the expression of hepatic pro-inflammatory cytokines, as well as inhibiting NF-?B expression.

SUBMITTER: Ma Q

PROVIDER: S-EPMC4690129 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Molecular Mechanisms of Lipoic Acid Protection against Aflatoxin B₁-Induced Liver Oxidative Damage and Inflammatory Responses in Broilers.

Ma Qiugang Q Li Yan Y Fan Yu Y Zhao Lihong L Wei Hua H Ji Cheng C Zhang Jianyun J

Toxins 20151214 12

Alpha-lipoic acid (α-LA) was evaluated in this study for its molecular mechanisms against liver oxidative damage and inflammatory responses induced by aflatoxin B₁ (AFB₁). Birds were randomly allocated into four groups with different diets for three weeks: a basal diet, a 300 mg/kg α-LA supplementation in a basal diet, a diet containing 74 μg/kg AFB₁, and 300 mg/kg α-LA supplementation in a diet containing 74 μg/kg AFB₁. In the AFB₁ group, the expression of GSH-PX mRNA was down-regulated (p < 0. ...[more]

PMID: 26694462

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Dataset Information

Molecular Mechanisms of Lipoic Acid Protection against Aflatoxin B?-Induced Liver Oxidative Damage and Inflammatory Responses in Broilers.

Publications

Molecular Mechanisms of Lipoic Acid Protection against Aflatoxin B₁-Induced Liver Oxidative Damage and Inflammatory Responses in Broilers.

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