Ontology highlight
ABSTRACT:
SUBMITTER: Ren A
PROVIDER: S-EPMC4690532 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Ren Aiming A Xue Yi Y Peselis Alla A Serganov Alexander A Al-Hashimi Hashim M HM Patel Dinshaw J DJ
Cell reports 20151119 9
Naturally occurring L-glutamine riboswitches occur in cyanobacteria and marine metagenomes, where they reside upstream of genes involved in nitrogen metabolism. By combining X-ray, NMR, and MD, we characterized an L-glutamine-dependent conformational transition in the Synechococcus elongatus glutamine riboswitch from tuning fork to L-shaped alignment of stem segments. This transition generates an open ligand-binding pocket with L-glutamine selectivity enforced by Mg(2+)-mediated intermolecular i ...[more]