Ontology highlight
ABSTRACT:
SUBMITTER: Mohamed A
PROVIDER: S-EPMC4690860 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Mohamed Adil A Johnston Randal N RN Shmulevitz Maya M
Viruses 20151201 12
Viruses that specifically replicate in tumor over normal cells offer promising cancer therapies. Oncolytic viruses (OV) not only kill the tumor cells directly; they also promote anti-tumor immunotherapeutic responses. Other major advantages of OVs are that they dose-escalate in tumors and can be genetically engineered to enhance potency and specificity. Unmodified wild type reovirus is a propitious OV currently in phase I-III clinical trials. This review summarizes modifications to reovirus that ...[more]