Herpesvirus gB: A Finely Tuned Fusion Machine.
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ABSTRACT:
SUBMITTER: Cooper RS
PROVIDER: S-EPMC4690880 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
Herpesvirus gB: A Finely Tuned Fusion Machine.
Cooper Rebecca S RS Heldwein Ekaterina E EE
Viruses 20151211 12
Enveloped viruses employ a class of proteins known as fusogens to orchestrate the merger of their surrounding envelope and a target cell membrane. Most fusogens accomplish this task alone, by binding cellular receptors and subsequently catalyzing the membrane fusion process. Surprisingly, in herpesviruses, these functions are distributed among multiple proteins: the conserved fusogen gB, the conserved gH/gL heterodimer of poorly defined function, and various non-conserved receptor-binding protei ...[more]
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