Ontology highlight
ABSTRACT:
SUBMITTER: Yue Y
PROVIDER: S-EPMC4691838 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
RNA (New York, N.Y.) 20151109 1
Mutually exclusive splicing is an important means of increasing the protein repertoire, by which the Down's syndrome cell adhesion molecule (Dscam) gene potentially generates 38,016 different isoforms in Drosophila melanogaster. However, the regulatory mechanisms remain obscure due to the complexity of the Dscam exon cluster. Here, we reveal a molecular model for the regulation of the mutually exclusive splicing of the serpent pre-mRNA based on competition between upstream and downstream RNA pai ...[more]