Ontology highlight
ABSTRACT:
SUBMITTER: Varland S
PROVIDER: S-EPMC4692089 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Varland Sylvia S Osberg Camilla C Arnesen Thomas T
Proteomics 20150616 14
The vast majority of eukaryotic proteins are N-terminally modified by one or more processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include different peptidases, transferases, and ligases. Methionine aminopeptidases excise the initiator methionine leaving the nascent polypeptide with a newly exposed amino acid that may be further modified. N-terminal acetyl-, methyl-, myristoyl-, and palmitoyltransferases may attach an acetyl, methyl, myristoyl, or palmitoyl group, ...[more]