Ontology highlight
ABSTRACT:
SUBMITTER: Serganov A
PROVIDER: S-EPMC4692365 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Serganov Alexander A Yuan Yu-Ren YR Pikovskaya Olga O Polonskaia Anna A Malinina Lucy L Phan Anh Tuân AT Hobartner Claudia C Micura Ronald R Breaker Ronald R RR Patel Dinshaw J DJ
Chemistry & biology 20041201 12
Metabolite-sensing mRNAs, or "riboswitches," specifically interact with small ligands and direct expression of the genes involved in their metabolism. Riboswitches contain sensing "aptamer" modules, capable of ligand-induced structural changes, and downstream regions, harboring expression-controlling elements. We report the crystal structures of the add A-riboswitch and xpt G-riboswitch aptamer modules that distinguish between bound adenine and guanine with exquisite specificity and modulate exp ...[more]