A Common Polymorphism in SCN2A Predicts General Cognitive Ability through Effects on PFC Physiology.
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ABSTRACT:
SUBMITTER: Scult MA
PROVIDER: S-EPMC4692714 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
A Common Polymorphism in SCN2A Predicts General Cognitive Ability through Effects on PFC Physiology.
Scult Matthew A MA Trampush Joey W JW Zheng Fengyu F Conley Emily Drabant ED Lencz Todd T Malhotra Anil K AK Dickinson Dwight D Weinberger Daniel R DR Hariri Ahmad R AR
Journal of cognitive neuroscience 20150511 9
Here we provide novel convergent evidence across three independent cohorts of healthy adults (n = 531), demonstrating that a common polymorphism in the gene encoding the α2 subunit of neuronal voltage-gated type II sodium channels (SCN2A) predicts human general cognitive ability or "g." Using meta-analysis, we demonstrate that the minor T allele of a common polymorphism (rs10174400) in SCN2A is associated with significantly higher "g" independent of gender and age. We further demonstrate using r ...[more]
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