Evolutionary Insights into IL17A in Lagomorphs.
Ontology highlight
ABSTRACT:
SUBMITTER: Neves F
PROVIDER: S-EPMC4692990 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Evolutionary Insights into IL17A in Lagomorphs.
Neves Fabiana F Abrantes Joana J Almeida Tereza T Costa Paulo P PP Esteves Pedro J PJ
Mediators of inflammation 20151215
In leporids, IL17A had been implicated in the host defense against extracellular pathogens, such as Francisella tularensis that infects hares and rabbits and causes the zoonotic disease tularemia. Here, we studied IL17A from five lagomorphs, European rabbit, pygmy rabbit, brush rabbit, European brown hare, and American pika. We observed that this protein is highly conserved between these species, with a similarity of 97-99% in leporids and ~88% between leporids and American pika. The exon/intron ...[more]
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