Genetics and genomics of psychiatric disease.
Ontology highlight
ABSTRACT:
SUBMITTER: Geschwind DH
PROVIDER: S-EPMC4694563 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
Genetics and genomics of psychiatric disease.
Geschwind Daniel H DH Flint Jonathan J
Science (New York, N.Y.) 20150924 6255
Large-scale genomic investigations have just begun to illuminate the molecular genetic contributions to major psychiatric illnesses, ranging from small-effect-size common variants to larger-effect-size rare mutations. The findings provide causal anchors from which to understand their neurobiological basis. Although these studies represent enormous success, they highlight major challenges reflected in the heterogeneity and polygenicity of all of these conditions and the difficulty of connecting m ...[more]
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