Ontology highlight
ABSTRACT:
SUBMITTER: Lawrimore J
PROVIDER: S-EPMC4694754 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Lawrimore Josh J Aicher Joseph K JK Hahn Patrick P Fulp Alyona A Kompa Ben B Vicci Leandra L Falvo Michael M Taylor Russell M RM Bloom Kerry K
Molecular biology of the cell 20151104 1
ChromoShake is a three-dimensional simulator designed to find the thermodynamically favored states for given chromosome geometries. The simulator has been applied to a geometric model based on experimentally determined positions and fluctuations of DNA and the distribution of cohesin and condensin in the budding yeast centromere. Simulations of chromatin in differing initial configurations reveal novel principles for understanding the structure and function of a eukaryotic centromere. The entrop ...[more]