Ontology highlight
ABSTRACT:
SUBMITTER: Colombo M
PROVIDER: S-EPMC4694956 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Colombo Michela M Galletti Serena S Garavelli Silvia S Platonova Natalia N Paoli Alessandro A Basile Andrea A Taiana Elisa E Neri Antonino A Chiaramonte Raffaella R
Oncotarget 20150901 29
Despite recent therapeutic advances, multiple myeloma (MM) is still an incurable neoplasia due to intrinsic or acquired resistance to therapy. Myeloma cell localization in the bone marrow milieu allows direct interactions between tumor cells and non-tumor bone marrow cells which promote neoplastic cell growth, survival, bone disease, acquisition of drug resistance and consequent relapse. Twenty percent of MM patients are at high-risk of treatment failure as defined by tumor markers or presentati ...[more]