Ontology highlight
ABSTRACT:
SUBMITTER: Colombo PE
PROVIDER: S-EPMC4695063 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Colombo Pierre-Emmanuel PE du Manoir Stanislas S Orsett Béatrice B Bras-Gonçalves Rui R Lambros Mario B MB MacKay Alan A Nguyen Tien-Tuan TT Boissière Florence F Pourquier Didier D Bibeau Frédéric F Reis-Filho Jorge S JS Theillet Charles C
Oncotarget 20150901 29
Advanced Epithelial Ovarian Cancer (EOC) patients frequently relapse by 24 months and develop resistant disease. Research on EOC therapies relies on cancer cell lines established decades ago making Patient Derived Xenografts (PDX) attractive models, because they are faithful representations of the original tumor. We established 35 ovarian cancer PDXs resulting from the original graft of 77 EOC samples onto immuno-compromised mice. PDXs covered the diversity of EOC histotypes and graft take was c ...[more]