Ontology highlight
ABSTRACT:
SUBMITTER: Chen MH
PROVIDER: S-EPMC4695139 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Chen Ming-Huang MH Yen Chueh-Chuan CC Cheng Chi-Tung CT Wu Ren-Chin RC Huang Shih-Chiang SC Yu Chung-Shan CS Chung Yi-Hsiu YH Liu Chun-Yu CY Chang Peter Mu-Hsin PM Chao Yee Y Chen Ming-Han MH Chen Yu-Fen YF Chiang Kun-Chun KC Yeh Ta-Sen TS Chen Tzu Chi TC Huang Chi-Ying F CY Yeh Chun-Nan CN
Oncotarget 20150901 27
Cholangiocarcinoma (CCA) is characterized by a uniquely aggressive behavior and lack of effective targeted therapies. After analyzing the gene expression profiles of seven paired intrahepatic CCA microarrays, a novel sphingosine kinase 1 (SPHK1)/sphingosine-1-phosphate (S1P) pathway and a novel target gene, SPHK1, were identified. We hypothesized that therapeutic targeting of this pathway can be used to kill intrahepatic cholangiocarcinoma (CCA) cells. High levels of SPHK1 protein expression, wh ...[more]