Ontology highlight
ABSTRACT:
SUBMITTER: Sahasrabuddhe NA
PROVIDER: S-EPMC4696065 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Sahasrabuddhe Nandini A NA Huang Tai-Chung TC Kumar Praveen P Yang Yi Y Ghosh Bidyut B Leach Steven D SD Chaerkady Raghothama R Pandey Akhilesh A
Biochemical and biophysical research communications 20150530 3
Dicer is an essential ribonuclease involved in the biogenesis of miRNAs. Previous studies have reported downregulation of Dicer in multiple cancers including hepatocellular carcinoma. To identify signaling pathways that are altered upon Dicer depletion, we carried out quantitative phosphotyrosine profiling of liver tissue from Dicer knockout mice. We employed antibody-based enrichment of phosphotyrosine containing peptides coupled with SILAC spike-in approach for quantitation. High resolution ma ...[more]