Ontology highlight
ABSTRACT:
SUBMITTER: Erpenbeck L
PROVIDER: S-EPMC4696577 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Erpenbeck Luise L Demers Melanie M Zsengellér Zsuzsanna K ZK Gallant Maureen M Cifuni Stephen M SM Stillman Isaac E IE Karumanchi S Ananth SA Wagner Denisa D DD
Journal of the American Society of Nephrology : JASN 20150602 1
Thrombotic microangiopathy (TMA) is a life-threatening condition that affects some, but not all, recipients of vascular endothelial growth factor (VEGF) inhibitors given as part of chemotherapy. TMA is also a complication of preeclampsia, a disease characterized by excess production of the VEGF-scavenging soluble VEGF receptor 1 (soluble fms-like tyrosine kinase 1; sFlt-1). Risk factors for VEGF inhibitor-related TMA remain unknown. We hypothesized that deficiency of the VWF-cleaving ADAMTS13 en ...[more]