Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase.
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ABSTRACT:
SUBMITTER: Brecher M
PROVIDER: S-EPMC4696607 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase.
Brecher Matthew M Chen Hui H Li Zhong Z Banavali Nilesh K NK Jones Susan A SA Zhang Jing J Kramer Laura D LD Li Hongmin H
ACS infectious diseases 20150731 8
Flavivirus methyltransferase (MTase) is essential for viral replication. Here we report the identification of small molecules through virtual screening that putatively bind to the SAM-binding site of flavivirus MTase and inhibit its function. Six of these computationally predicted binders were identified to show significant MTase inhibition with low micromolar inhibitory activity. The most active compounds showed broad-spectrum activity against the MTase proteins of other flaviviruses. Two of th ...[more]
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