On the Recombination Rate Estimation in the Presence of Population Substructure.
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ABSTRACT:
SUBMITTER: Hecker J
PROVIDER: S-EPMC4696844 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
On the Recombination Rate Estimation in the Presence of Population Substructure.
Hecker Julian J Prokopenko Dmitry D Lange Christoph C Fier Heide Löhlein HL
PloS one 20151230 12
As recombination events are not uniformly distributed along the human genome, the estimation of fine-scale recombination maps, e.g. HapMap Project, has been one of the major research endeavors over the last couple of years. For simulation studies, these estimates provide realistic reference scenarios to design future study and to develop novel methodology. To achieve a feasible framework for the estimation of such recombination maps, existing methodology uses sample probabilities for a two-locus ...[more]
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