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A neuromarker of sustained attention from whole-brain functional connectivity.


ABSTRACT: Although attention plays a ubiquitous role in perception and cognition, researchers lack a simple way to measure a person's overall attentional abilities. Because behavioral measures are diverse and difficult to standardize, we pursued a neuromarker of an important aspect of attention, sustained attention, using functional magnetic resonance imaging. To this end, we identified functional brain networks whose strength during a sustained attention task predicted individual differences in performance. Models based on these networks generalized to previously unseen individuals, even predicting performance from resting-state connectivity alone. Furthermore, these same models predicted a clinical measure of attention--symptoms of attention deficit hyperactivity disorder--from resting-state connectivity in an independent sample of children and adolescents. These results demonstrate that whole-brain functional network strength provides a broadly applicable neuromarker of sustained attention.

SUBMITTER: Rosenberg MD 

PROVIDER: S-EPMC4696892 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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A neuromarker of sustained attention from whole-brain functional connectivity.

Rosenberg Monica D MD   Finn Emily S ES   Scheinost Dustin D   Papademetris Xenophon X   Shen Xilin X   Constable R Todd RT   Chun Marvin M MM  

Nature neuroscience 20151123 1


Although attention plays a ubiquitous role in perception and cognition, researchers lack a simple way to measure a person's overall attentional abilities. Because behavioral measures are diverse and difficult to standardize, we pursued a neuromarker of an important aspect of attention, sustained attention, using functional magnetic resonance imaging. To this end, we identified functional brain networks whose strength during a sustained attention task predicted individual differences in performan  ...[more]

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