Ontology highlight
ABSTRACT:
SUBMITTER: Abdouh M
PROVIDER: S-EPMC4697155 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Abdouh Mohamed M Hanna Roy R El Hajjar Jida J Flamier Anthony A Bernier Gilbert G
The Journal of biological chemistry 20151014 1
The polycomb repressive complex 1 (PRC1), containing the core BMI1 and RING1A/B proteins, mono-ubiquitinylates histone H2A (H2A(ub)) and is associated with silenced developmental genes at facultative heterochromatin. It is, however, assumed that the PRC1 is excluded from constitutive heterochromatin in somatic cells based on work performed on mouse embryonic stem cells and oocytes. We show here that BMI1 is required for constitutive heterochromatin formation and silencing in human and mouse soma ...[more]