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Isocyanates and work-related asthma: Findings from California, Massachusetts, Michigan, and New Jersey, 1993-2008.


ABSTRACT: Isocyanates remain a leading cause of work-related asthma (WRA).Two independent data systems were analyzed for the period 1993-2008: (1) State-based WRA case surveillance data on persons with isocyanate-induced WRA from four states, and (2) Occupational Safety and Health Administration (OSHA) Integrated Management Information System (IMIS) isocyanate air sampling results.We identified 368 cases of isocyanate-induced WRA from 32 industries and 678 OSHA isocyanate air samples with detectable levels from 31 industries. Seventeen industries were unique to one or the other dataset.Isocyanate-induced WRA continues to occur in a wide variety of industries. Two data systems uncovered industries with isocyanate exposures and/or illness. Improved control measures and standards, including medical surveillance, are needed. More emphasis is needed on task-specific guidance, spill clean-up procedures, skin and respiratory protection, and targeted medical monitoring to mitigate the hazards of isocyanate use.

SUBMITTER: Lefkowitz D 

PROVIDER: S-EPMC4697263 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Isocyanates and work-related asthma: Findings from California, Massachusetts, Michigan, and New Jersey, 1993-2008.

Lefkowitz Daniel D   Pechter Elise E   Fitzsimmons Kathleen K   Lumia Margaret M   Stephens Alicia C AC   Davis Letitia L   Flattery Jennifer J   Weinberg Justine J   Harrison Robert J RJ   Reilly Mary Jo MJ   Filios Margaret S MS   White Gretchen E GE   Rosenman Kenneth D KD  

American journal of industrial medicine 20150909 11


<h4>Background</h4>Isocyanates remain a leading cause of work-related asthma (WRA).<h4>Methods</h4>Two independent data systems were analyzed for the period 1993-2008: (1) State-based WRA case surveillance data on persons with isocyanate-induced WRA from four states, and (2) Occupational Safety and Health Administration (OSHA) Integrated Management Information System (IMIS) isocyanate air sampling results.<h4>Results</h4>We identified 368 cases of isocyanate-induced WRA from 32 industries and 67  ...[more]

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