Ontology highlight
ABSTRACT:
SUBMITTER: Naik RP
PROVIDER: S-EPMC4697437 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Hematology. American Society of Hematology. Education Program 20150101
The sickle hemoglobin (HbS) point mutation has independently undergone evolutionary selection at least five times in the world because of its overwhelming malarial protective effects in the heterozygous state. In 1949, homozygous Hb S or sickle cell disease (SCD) became the first inherited condition identified at the molecular level; however, since then, both SCD and heterozygous Hb S, sickle cell trait (SCT), have endured a long and complicated history. Hasty adoption of early mass screening pr ...[more]