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Human Adenovirus 36 Infection Increased the Risk of Obesity: A Meta-Analysis Update.

ABSTRACT: Human adenovirus 36 (HAdV-36), as the key pathogen, was supposed and discussed to be associated with obesity. We searched the references on the association between HAdV-36 infection and obesity with the different epidemiological methods, to explore the relationship with a larger sample size by meta-analysis and compare the differences of epidemiological methods and population subsets by the subgroup analyses.We conducted literature search on the association between HAdV-36 infections and obesity in English or Chinese published up to July 1, 2015. The primary outcome was the HAdV-36 infection rate in the obese and lean groups; the secondary outcomes were the BMI level and BMI z-score in the HAdV-36 positive and negative groups. The pooled odds ratio (OR) was calculated for the primary outcome; the standardized mean differences (SMDs) were calculated for the secondary and third outcomes. Prediction interval (PI) was graphically presented in the forest plot of the random effect meta-analyses. Metaregression analysis and subgroup analysis were performed.Finally 24 references with 10,191 study subjects were included in the meta-analysis. The obesity subjects were more likely to be infected with HAdV-36 compared to the lean controls (OR?=?2.00; 95%CI: 1.46, 2.74; PI: 0.59, 6.76; P?

SUBMITTER: Xu MY

PROVIDER: S-EPMC4698001 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Human Adenovirus 36 Infection Increased the Risk of Obesity: A Meta-Analysis Update.

Xu Mei-Yan MY Cao Bing B Wang Dong-Fang DF Guo Jing-Hui JH Chen Kai-Li KL Shi Mai M Yin Jian J Lu Qing-Bin QB

Medicine 20151201 51

Human adenovirus 36 (HAdV-36), as the key pathogen, was supposed and discussed to be associated with obesity. We searched the references on the association between HAdV-36 infection and obesity with the different epidemiological methods, to explore the relationship with a larger sample size by meta-analysis and compare the differences of epidemiological methods and population subsets by the subgroup analyses.We conducted literature search on the association between HAdV-36 infections and obesity ...[more]

PMID: 26705235

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Project description:BackgroundSeveral studies have shown that Adenovirus 36 (Ad36) influences the risk of obesity in humans. Clarifying the relationship between Ad36 infection and obesity could lead to more effective approaches for the management of obesity. The objective of this study was to conduct a meta-analysis to confirm the influence of Ad36 infection on obesity and metabolic markers.Methodology/principal findingsWe searched MEDLINE and the Cochrane Library for pertinent articles (including their references) published between 1951 and April 22, 2012. Only English language reports of original observational studies were included in this meta-analysis. Data extraction was performed independently by two reviewers. Weighted mean differences (WMDs) and pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated using the random effects model. Of 237 potentially relevant studies, 10 cross-sectional studies (n?=?2,870) conformed to the selection criteria. Pooled analysis showed that the WMD for BMI of Ad36 infection compared with non-infection was 3.19 (95% CI 1.44-4.93; P<0.001). Sensitivity analysis restricted to studies of adults yielded a similar result of 3.18 (95% CI 0.78-5.57; P?=?0.009). The increased risk of obesity associated with Ad36 infection was also significant (OR: 1.9; 95% CI: 1.01-3.56; P?=?0.047). No significant differences were found in relation to total cholesterol (P?=?0.83), triglycerides (P?=?0.64), HDL (P?=?0.69), blood glucose (P?=?0.08), waist circumstance (P?=?0.09), and systolic blood pressure (P?=?0.25).Conclusion/significanceAd36 infection was associated with the risk of obesity and weight gain, but was not associated with abnormal metabolic markers including waist circumstance. It suggests that Ad36 infection is more associated with accumulation of subcutaneous fat than that of visceral fat. The relationship between Ad36 and obesity should be assessed by further studies, including well-designed prospective studies, to gain a better understanding of whether Ad36 plays a role in the etiology of human obesity.

Dataset Information

Human Adenovirus 36 Infection Increased the Risk of Obesity: A Meta-Analysis Update.

Publications

Human Adenovirus 36 Infection Increased the Risk of Obesity: A Meta-Analysis Update.

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