Ontology highlight
ABSTRACT:
SUBMITTER: Saxton RA
PROVIDER: S-EPMC4698039 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Saxton Robert A RA Knockenhauer Kevin E KE Wolfson Rachel L RL Chantranupong Lynne L Pacold Michael E ME Wang Tim T Schwartz Thomas U TU Sabatini David M DM
Science (New York, N.Y.) 20151119 6268
Eukaryotic cells coordinate growth with the availability of nutrients through the mechanistic target of rapamycin complex 1 (mTORC1), a master growth regulator. Leucine is of particular importance and activates mTORC1 via the Rag guanosine triphosphatases and their regulators GATOR1 and GATOR2. Sestrin2 interacts with GATOR2 and is a leucine sensor. Here we present the 2.7 angstrom crystal structure of Sestrin2 in complex with leucine. Leucine binds through a single pocket that coordinates its c ...[more]