Ontology highlight
ABSTRACT:
SUBMITTER: O'Brien PD
PROVIDER: S-EPMC4698064 | biostudies-literature | 2016 Jan-Feb
REPOSITORIES: biostudies-literature
O'Brien Phillipe D PD Hur Junguk J Robell Nicholas J NJ Hayes John M JM Sakowski Stacey A SA Feldman Eva L EL
Journal of diabetes and its complications 20151003 1
<h4>Aims</h4>To identify a female mouse model of diabetic peripheral neuropathy (DPN), we characterized DPN in female BTBR ob/ob mice and compared their phenotype to non-diabetic and gender-matched controls. We also identified dysregulated genes and pathways in sciatic nerve (SCN) and dorsal root ganglia (DRG) of female BTBR ob/ob mice to determine potential DPN mechanisms.<h4>Methods</h4>Terminal neuropathy phenotyping consisted of examining latency to heat stimuli, sciatic motor and sural sens ...[more]