Ontology highlight
ABSTRACT:
SUBMITTER: Qi Y
PROVIDER: S-EPMC4698587 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Qi Yue Y Purtell Louise L Fu Melissa M Lee Nicola J NJ Aepler Julia J Zhang Lei L Loh Kim K Enriquez Ronaldo F RF Baldock Paul A PA Zolotukhin Sergei S Campbell Lesley V LV Herzog Herbert H
Scientific reports 20160104
Prader-Willi syndrome (PWS) is the predominant genetic cause of obesity in humans. Recent clinical reports have suggested that micro-deletion of the Snord116 gene cluster can lead to PWS, however, the extent of the contributions of the encoded snoRNAs is unknown. Here we show that mice lacking Snord116 globally have low birth weight, increased body weight gain, energy expenditure and hyperphagia. Consistent with this, microarray analysis of hypothalamic gene expression revealed a significant alt ...[more]