Ontology highlight
ABSTRACT:
SUBMITTER: Zheng S
PROVIDER: S-EPMC4699014 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Zheng Shirong S Coventry Susan S Cai Lu L Powell David W DW Jala Venkatakrishna R VR Haribabu Bodduluri B Epstein Paul N PN
Journal of diabetes research 20151220
In diabetic nephropathy (DN) proinflammatory chemokines and leukocyte infiltration correlate with tubulointerstitial injury and declining renal function. The atypical chemokine receptor ACKR2 is a chemokine scavenger receptor which binds and sequesters many inflammatory CC chemokines but does not transduce typical G-protein mediated signaling events. ACKR2 is known to regulate diverse inflammatory diseases but its role in DN has not been tested. In this study, we utilized ACKR2(-/-) mice to test ...[more]