Relative Movements of Domains in Large Molecules of the Immune System.
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ABSTRACT:
SUBMITTER: Schreiner W
PROVIDER: S-EPMC4699016 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Relative Movements of Domains in Large Molecules of the Immune System.
Schreiner Wolfgang W Karch Rudolf R Ribarics Reiner R Cibena Michael M Ilieva Nevena N
Journal of immunology research 20151221
Molecular dynamics was used to simulate large molecules of the immune system (major histocompatibility complex class I, presented epitope, T-cell receptor, and a CD8 coreceptor.) To characterize the relative orientation and movements of domains local coordinate systems (based on principal component analysis) were generated and directional cosines and Euler angles were computed. As a most interesting result, we found that the presence of the coreceptor seems to influence the dynamics within the p ...[more]
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