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Two new phenolic compounds from the leaves of Alnus sibirica Fisch. ex Turcz.


ABSTRACT: Two new phenolic compounds, 4-O-glucopyranosyl-5-O-caffeoylshikimic acid (1) and 2,3-digalloyl oregonin (2), were isolated along with eight known phenolic compounds (3-10) from an 80% acetone extract of Alnus sibirica leaves. The chemical structures of these compounds were elucidated using 1D/2D nuclear magnetic resonance and high resolution-MS. The anti-oxidative activities of these compounds were determined by assaying their 1,1-diphenyl-2-picrylhydrazyl radical and nitroblue tetrazolium superoxide anion scavenging activity. All of the isolated phenolic compounds (1-10) exhibited potent anti-oxidative activities. In particular, 2 and 4, which are diarylheptanoids, and 10 which is ellagitannin exhibited excellent anti-oxidative activities with almost the same potency as that of the positive controls L-ascorbic acid and allopurinol.

SUBMITTER: Kim MH 

PROVIDER: S-EPMC4699475 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Two new phenolic compounds from the leaves of Alnus sibirica Fisch. ex Turcz.

Kim Manh Heun MH   Park Kwan Hee KH   Kim So Ra SR   Park Kwang Jun KJ   Oh Myeong Hwan MH   Heo Jun Hyeok JH   Yoon Ki Hoon KH   Yin Jun J   Yoon Kyu Hyung KH   Lee Min Won MW  

Natural product research 20150727 2


Two new phenolic compounds, 4-O-glucopyranosyl-5-O-caffeoylshikimic acid (1) and 2,3-digalloyl oregonin (2), were isolated along with eight known phenolic compounds (3-10) from an 80% acetone extract of Alnus sibirica leaves. The chemical structures of these compounds were elucidated using 1D/2D nuclear magnetic resonance and high resolution-MS. The anti-oxidative activities of these compounds were determined by assaying their 1,1-diphenyl-2-picrylhydrazyl radical and nitroblue tetrazolium super  ...[more]

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