Ontology highlight
ABSTRACT:
SUBMITTER: Chruewkamlow N
PROVIDER: S-EPMC4699769 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Chruewkamlow Nuttapol N Mahasongkram Kodchakorn K Pata Supansa S Chaiwarith Romanee R Salee Parichart P Supparatpinyo Khuanchai K Kasinrerk Watchara W
PloS one 20160104 1
Autoantibodies against interferon-gamma (IFN-γ) can cause immunodeficiency and are associated with various opportunistic infections. In the present study, we investigated other cellular immune parameters for a better understanding of the immunodeficiency condition in the patients. The numbers of WBC, monocytes and NK cells were increased in patients with anti-IFN-γ autoantibodies (AAbs). Upon TCR activation, T cell proliferation and IL-2 receptor of the patients remained intact. Nonetheless, the ...[more]