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Immune Alterations in Patients with Anti-Interferon-? Autoantibodies.


ABSTRACT: Autoantibodies against interferon-gamma (IFN-?) can cause immunodeficiency and are associated with various opportunistic infections. In the present study, we investigated other cellular immune parameters for a better understanding of the immunodeficiency condition in the patients. The numbers of WBC, monocytes and NK cells were increased in patients with anti-IFN-? autoantibodies (AAbs). Upon TCR activation, T cell proliferation and IL-2 receptor of the patients remained intact. Nonetheless, the Th1 cytokine (IFN-? and TNF-?) production was up-regulated. The production of Th2 (IL-4) and Th17 (IL-17) cytokines was unchanged. We suggest that, in addition to the presence of anti-IFN-? autoantibodies, alterations in the cellular immune functions may also contribute to this immunodeficiency.

SUBMITTER: Chruewkamlow N 

PROVIDER: S-EPMC4699769 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Autoantibodies against interferon-gamma (IFN-γ) can cause immunodeficiency and are associated with various opportunistic infections. In the present study, we investigated other cellular immune parameters for a better understanding of the immunodeficiency condition in the patients. The numbers of WBC, monocytes and NK cells were increased in patients with anti-IFN-γ autoantibodies (AAbs). Upon TCR activation, T cell proliferation and IL-2 receptor of the patients remained intact. Nonetheless, the  ...[more]

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