Ontology highlight
ABSTRACT:
SUBMITTER: Fauth M
PROVIDER: S-EPMC4699846 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Fauth Michael M Wörgötter Florentin F Tetzlaff Christian C
PLoS computational biology 20151229 12
A long-standing problem is how memories can be stored for very long times despite the volatility of the underlying neural substrate, most notably the high turnover of dendritic spines and synapses. To address this problem, here we are using a generic and simple probabilistic model for the creation and removal of synapses. We show that information can be stored for several months when utilizing the intrinsic dynamics of multi-synapse connections. In such systems, single synapses can still show hi ...[more]