Ontology highlight
ABSTRACT:
SUBMITTER: Kieckbusch J
PROVIDER: S-EPMC4700049 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Cell reports 20151217 12
Maternal immune cells are an integral part of reproduction, but how they might cause pregnancy complications remains elusive. Macrophages and their dual function in inflammation and tissue repair are thought to play key yet undefined roles. Altered perinatal growth underpins adult morbidity, and natural killer (NK) cells may sustain fetal growth by establishing the placental blood supply. Using a mouse model of genetic inactivation of PI3K p110δ, a key intracellular signaling molecule in leukocy ...[more]