Ontology highlight
ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC4700112 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Li Shaoyong S Ling Chen C Zhong Li L Li Mengxin M Su Qin Q He Ran R Tang Qiushi Q Greiner Dale L DL Shultz Leonard D LD Brehm Michael A MA Flotte Terence R TR Mueller Christian C Srivastava Arun A Gao Guangping G
Molecular therapy : the journal of the American Society of Gene Therapy 20150925 12
Recombinant adeno-associated virus serotype 3B (rAAV3B) can transduce cultured human liver cancer cells and primary human hepatocytes efficiently. Serine (S)- and threonine (T)-directed capsid modifications further augment its transduction efficiency. Systemically delivered capsid-optimized rAAV3B vectors can specifically target cancer cells in a human liver cancer xenograft model, suggesting their potential use for human liver-directed gene therapy. Here, we compared transduction efficiencies o ...[more]