How type 1 fimbriae help Escherichia coli to evade extracellular antibiotics.
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ABSTRACT:
SUBMITTER: Avalos Vizcarra I
PROVIDER: S-EPMC4700443 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
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How type 1 fimbriae help Escherichia coli to evade extracellular antibiotics.
Avalos Vizcarra Ima I Hosseini Vahid V Kollmannsberger Philip P Meier Stefanie S Weber Stefan S SS Arnoldini Markus M Ackermann Martin M Vogel Viola V
Scientific reports 20160105
To survive antibiotics, bacteria use two different strategies: counteracting antibiotic effects by expression of resistance genes or evading their effects e.g. by persisting inside host cells. Since bacterial adhesins provide access to the shielded, intracellular niche and the adhesin type 1 fimbriae increases bacterial survival chances inside macrophages, we asked if fimbriae also influenced survival by antibiotic evasion. Combined gentamicin survival assays, flow cytometry, single cell microsc ...[more]
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