Neutrophils support lung colonization of metastasis-initiating breast cancer cells.

ABSTRACT: Despite progress in the development of drugs that efficiently target cancer cells, treatments for metastatic tumours are often ineffective. The now well-established dependency of cancer cells on their microenvironment suggests that targeting the non-cancer-cell component of the tumour might form a basis for the development of novel therapeutic approaches. However, the as-yet poorly characterized contribution of host responses during tumour growth and metastatic progression represents a limitation to exploiting this approach. Here we identify neutrophils as the main component and driver of metastatic establishment within the (pre-)metastatic lung microenvironment in mouse breast cancer models. Neutrophils have a fundamental role in inflammatory responses and their contribution to tumorigene

SUBMITTER: Wculek SK 

PROVIDER: S-EPMC4700594 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature