Ontology highlight
ABSTRACT:
SUBMITTER: Raetz EA
PROVIDER: S-EPMC4701208 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Raetz Elizabeth A EA Cairo Mitchell S MS Borowitz Michael J MJ Lu Xiaomin X Devidas Meenakshi M Reid Joel M JM Goldenberg David M DM Wegener William A WA Zeng Hui H Whitlock James A JA Adamson Peter C PC Hunger Stephen P SP Carroll William L WL
Pediatric blood & cancer 20150302 7
<h4>Background</h4>Given the success of immunotherapeutic approaches in hematologic malignancies, the COG designed a phase I/II study to determine whether the addition of epratuzumab (anti-CD22) to an established chemotherapy platform improves rates of second remission (CR2) in pediatric patients with B-lymphoblastic leukemia (B-ALL) and early bone marrow relapse.<h4>Procedure</h4>Therapy consisted of three established blocks of re-induction chemotherapy. Epratuzumab (360 mg/m(2)/dose) was combi ...[more]