Ontology highlight
ABSTRACT:
SUBMITTER: Kelley ST
PROVIDER: S-EPMC4701222 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Kelley Scott T ST Skarra Danalea V DV Rivera Alissa J AJ Thackray Varykina G VG
PloS one 20160105 1
Women with polycystic ovary syndrome (PCOS) have reproductive and metabolic abnormalities that result in an increased risk of infertility, diabetes and cardiovascular disease. The large intestine contains a complex community of microorganisms (the gut microbiome) that is dysregulated in humans with obesity and type 2 diabetes. Using a letrozole-induced PCOS mouse model, we demonstrated significant diet-independent changes in the gut microbial community, suggesting that gut microbiome dysbiosis m ...[more]