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Exploring the Spatial Association between Social Deprivation and Cardiovascular Disease Mortality at the Neighborhood Level.

ABSTRACT: Cardiovascular disease (CVD), the leading cause of death in the United States, is impacted by neighborhood-level factors including social deprivation. To measure the association between social deprivation and CVD mortality in Harris County, Texas, global (Ordinary Least Squares (OLS) and local (Geographically Weighted Regression (GWR)) models were built. The models explored the spatial variation in the relationship at a census-tract level while controlling for age, income by race, and education. A significant and spatially varying association (p < .01) was found between social deprivation and CVD mortality, when controlling for all other factors in the model. The GWR model provided a better model fit over the analogous OLS model (R2 = .65 vs. .57), reinforcing the importance of geography and neighborhood of residence in the relationship between social deprivation and CVD mortality. Findings from the GWR model can be used to identify neighborhoods at greatest risk for poor health outcomes and to inform the placement of community-based interventions.

SUBMITTER: Ford MM

PROVIDER: S-EPMC4701397 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Exploring the Spatial Association between Social Deprivation and Cardiovascular Disease Mortality at the Neighborhood Level.

Ford Mary Margaret MM Highfield Linda D LD

PloS one 20160105 1

Cardiovascular disease (CVD), the leading cause of death in the United States, is impacted by neighborhood-level factors including social deprivation. To measure the association between social deprivation and CVD mortality in Harris County, Texas, global (Ordinary Least Squares (OLS) and local (Geographically Weighted Regression (GWR)) models were built. The models explored the spatial variation in the relationship at a census-tract level while controlling for age, income by race, and education. ...[more]

PMID: 26731424

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Project description:Low socioeconomic status (SES) and living in a disadvantaged neighborhood are associated with poor cardiovascular health. Multiple lines of evidence have linked DNA methylation to both cardiovascular risk factors and social disadvantage indicators. However, limited research has investigated the role of DNA methylation in mediating the associations of individual- and neighborhood-level disadvantage with multiple cardiovascular risk factors in large, multi-ethnic, population-based cohorts. We examined whether disadvantage at the individual level (childhood and adult SES) and neighborhood level (summary neighborhood SES as assessed by Census data and social environment as assessed by perceptions of aesthetic quality, safety, and social cohesion) were associated with 11 cardiovascular risk factors including measures of obesity, diabetes, lipids, and hypertension in 1,154 participants from the Multi-Ethnic Study of Atherosclerosis (MESA). For significant associations, we conducted epigenome-wide mediation analysis to identify methylation sites mediating the relationship between individual/neighborhood disadvantage and cardiovascular risk factors using the JT-Comp method that assesses sparse mediation effects under a composite null hypothesis. In models adjusting for age, sex, race/ethnicity, smoking, medication use, and genetic principal components of ancestry, epigenetic mediation was detected for the associations of adult SES with body mass index (BMI), insulin, and high-density lipoprotein cholesterol (HDL-C), as well as for the association between neighborhood socioeconomic disadvantage and HDL-C at FDR q < 0.05. The 410 CpG mediators identified for the SES-BMI association were enriched for CpGs associated with gene expression (expression quantitative trait methylation loci, or eQTMs), and corresponding genes were enriched in antigen processing and presentation pathways. For cardiovascular risk factors other than BMI, most of the epigenetic mediators lost significance after controlling for BMI. However, 43 methylation sites showed evidence of mediating the neighborhood socioeconomic disadvantage and HDL-C association after BMI adjustment. The identified mediators were enriched for eQTMs, and corresponding genes were enriched in inflammatory and apoptotic pathways. Our findings support the hypothesis that DNA methylation acts as a mediator between individual- and neighborhood-level disadvantage and cardiovascular risk factors, and shed light on the potential underlying epigenetic pathways. Future studies are needed to fully elucidate the biological mechanisms that link social disadvantage to poor cardiovascular health.

Project description:Housing prices are known to be a relevant indicator of the socioeconomic position of the neighborhood. In a society where the market system mainly drives housing prices, residents' spatial patterning is formulated according to their socioeconomic position. Dividing the 2013–2018 entire study period into three periods, we explored the spatial distribution of housing prices and all-cause mortality and their association in Seoul, the country's capital city. The government authorities' data and 2015 census data were used for the study. We mapped the spatial distribution of housing prices and all-cause mortality and investigated the changes in distribution. We conducted a pooled ordinary least square (OLS) and spatial panel regression analysis to estimate housing prices elasticity of all-cause mortality. We also explored the possible mediating role of housing prices on the educational composition's effect on all-cause mortality. We found the common trends of increasing spatial patterning of housing prices and all-cause mortality. The magnitude of spatial patterning was far greater in housing prices than all-cause mortality. A pooled OLS regression analysis found that a 1% increase in housing price was associated with a 0.11% reduction in all-cause mortality after controlling the explanatory variables. Attenuation in the regression coefficient's magnitude was found after adding the neighborhood's educational composition to the model. As a result of spatial panel analysis, we found a direction and scale similar to the housing price elasticity of all-cause mortality in the final pooled OLS model. The results suggested that spatial health inequality in Korea's urban space mainly stems from socioeconomic inequality. Highlights • Korea's housing system is highly market-driven, and the distribution of housing prices is spatially patterned.• Doubling the neighborhood-level price of housing reduced all-cause mortality by 5% after adjusting neighborhood-level factors.• Housing prices and educational composition were related and explained part of the variance of all-cause mortality.

Project description:Social determinants of health are implicated in the geographic variation in cardiovascular diseases (CVDs). The social vulnerability index (SVI) is an estimate of a neighborhood's potential for deleterious outcomes when faced with natural disasters or disease outbreaks. We sought to investigate the association of the SVI with cardiovascular risk factors and the prevalence of coronary heart disease (CHD) in the United States at the census tract level. We linked census tract SVI with prevalence of census tract CVD risk factors (smoking, high cholesterol, diabetes, high blood pressure, low physical activity and obesity), and prevalence of CHD obtained from the behavioral risk factor surveillance system. We evaluated the association between SVI, its sub-scales, CVD risk factors and CHD prevalence using linear regression. Among 72,173 census tracts, prevalence of all cardiovascular risk factors increased linearly with SVI. A higher SVI was associated with a higher CHD prevalence (R2 = 0.17, P < 0.0001). The relationship between SVI and CHD was stronger when accounting for census-tract median age (R2 = 0.57, P < 0.0001). A multivariable linear regression model including 4 SVI themes separately explained considerably more variation in CHD prevalence than the composite SVI alone (50.0% vs 17.3%). Socioeconomic status and household composition and disability were the SVI themes most closely associated with cardiovascular risk factors and CHD prevalence. In the United States, social vulnerability can explain significant portion of geographic variation in CHD, and its risk factors. Neighborhoods with high social vulnerability are at disproportionately increased risk of CHD and its risk factors. Social determinants of health are implicated in the geographic variation in cardiovascular diseases (CVDs). We investigated the association of social vulnerability index (SVI) with cardiovascular risk factors and the prevalence of coronary heart disease (CHD) in the United States at the census tract level. We show that cardiovascular risk factors and CHD were more common with higher SVI. A multivariable linear regression model including 4 SVI themes separately explained considerably more variation in CHD prevalence than the composite SVI alone (50.0% vs 17.3%). Socioeconomic status and household composition and/or disability were the SVI themes most closely associated with cardiovascular risk factors and CHD prevalence.

Dataset Information

Exploring the Spatial Association between Social Deprivation and Cardiovascular Disease Mortality at the Neighborhood Level.

Publications

Exploring the Spatial Association between Social Deprivation and Cardiovascular Disease Mortality at the Neighborhood Level.

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