Calcium Signaling Is Required for Erythroid Enucleation.
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ABSTRACT:
SUBMITTER: Wolwer CB
PROVIDER: S-EPMC4701494 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Calcium Signaling Is Required for Erythroid Enucleation.
Wölwer Christina B CB Pase Luke B LB Russell Sarah M SM Humbert Patrick O PO
PloS one 20160105 1
Although erythroid enucleation, the property of erythroblasts to expel their nucleus, has been known for 7ore than a century, surprisingly little is known regarding the molecular mechanisms governing this unique developmental process. Here we show that similar to cytokinesis, nuclear extrusion requires intracellular calcium signaling and signal transduction through the calmodulin (CaM) pathway. However, in contrast to cytokinesis we found that orthochromatic erythroblasts require uptake of extra ...[more]
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