Ontology highlight
ABSTRACT:
SUBMITTER: Cole CB
PROVIDER: S-EPMC4701540 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Cole Christopher B CB Verdoni Angela M AM Ketkar Shamika S Leight Elizabeth R ER Russler-Germain David A DA Lamprecht Tamara L TL Demeter Ryan T RT Magrini Vincent V Ley Timothy J TJ
The Journal of clinical investigation 20151123 1
The DNA methyltransferases DNMT3A and DNMT3B are primarily responsible for de novo methylation of specific cytosine residues in CpG dinucleotides during mammalian development. While loss-of-function mutations in DNMT3A are highly recurrent in acute myeloid leukemia (AML), DNMT3A mutations are almost never found in AML patients with translocations that create oncogenic fusion genes such as PML-RARA, RUNX1-RUNX1T1, and MLL-AF9. Here, we explored how DNMT3A is involved in the function of these fusi ...[more]