Ontology highlight
ABSTRACT:
SUBMITTER: Storck SE
PROVIDER: S-EPMC4701557 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Storck Steffen E SE Meister Sabrina S Nahrath Julius J Meißner Julius N JN Schubert Nils N Di Spiezio Alessandro A Baches Sandra S Vandenbroucke Roosmarijn E RE Bouter Yvonne Y Prikulis Ingrid I Korth Carsten C Weggen Sascha S Heimann Axel A Schwaninger Markus M Bayer Thomas A TA Pietrzik Claus U CU
The Journal of clinical investigation 20151130 1
According to the neurovascular hypothesis, impairment of low-density lipoprotein receptor-related protein-1 (LRP1) in brain capillaries of the blood-brain barrier (BBB) contributes to neurotoxic amyloid-β (Aβ) brain accumulation and drives Alzheimer's disease (AD) pathology. However, due to conflicting reports on the involvement of LRP1 in Aβ transport and the expression of LRP1 in brain endothelium, the role of LRP1 at the BBB is uncertain. As global Lrp1 deletion in mice is lethal, appropriate ...[more]