Ontology highlight
ABSTRACT:
SUBMITTER: Oruganty K
PROVIDER: S-EPMC4702295 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Oruganty Krishnadev K Talevich Eric E EE Neuwald Andrew F AF Kannan Natarajan N
BMC evolutionary biology 20160106
<h4>Background</h4>Many prokaryotic kinases that phosphorylate small molecule substrates, such as antibiotics, lipids and sugars, are evolutionarily related to Eukaryotic Protein Kinases (EPKs). These Eukaryotic-Like Kinases (ELKs) share the same overall structural fold as EPKs, but differ in their modes of regulation, substrate recognition and specificity-the sequence and structural determinants of which are poorly understood.<h4>Results</h4>To better understand the basis for ELK specificity, w ...[more]