Longitudinal changes in infant body composition: association with childhood obesity.
Ontology highlight
ABSTRACT: Rapid weight gain in infancy has been established as a risk factor for the development of later obesity.We aimed to investigate the role of changes in infant body composition (assessed via total body electrical conductivity) on the development of overweight/obesity in mid-childhood.Fifty-three term infants were evaluated at birth, three times during infancy and in mid-childhood. Logistic regression was used to determine associations between rates of total weight gain, fat mass gain and lean mass gain during infancy and later overweight/obesity (defined as body mass index [BMI] ?85th percentile), adjusted for birth weight and parent education.At follow-up (age 9.0?±?1.8 years), 30% were overweight/obese. More rapid total weight gain from 0 to 4 months was associated with twofold odds (odds ratio [OR] 1.98, 95% confidence interval [CI] 1.05-3.74, P?=?0.04) of overweight/obesity in mid-childhood. From 0 to 8 months, more rapid weight gain was associated with nearly fivefold odds (OR 4.76, 95% CI 1.05-21.5, P?=?0.04), and more rapid fat mass gain was associated with eightfold odds (OR 8.03, 95% CI 1.11-58.2, P?=?0.04) of later overweight/obesity.This exploratory study suggests that rapid weight gain, especially fat mass gain, in earlier infancy predisposes to mid-childhood overweight/obesity.
SUBMITTER: Koontz MB
PROVIDER: S-EPMC4702488 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
ACCESS DATA